Building Muscle: Molecular Regulation of Myogenesis - adult myogenesis


adult myogenesis -

Introduction. In this review, we discuss recent achievements in the studies of adult myogenesis and, specifically, on publications that carried major advances in our understanding of the cellular and molecular regulation of the muscle fibers’ satellite cells biology.Cited by: 451. Myogenesis in adult skeletal muscle (regeneration after injury) depends on the activation of muscle-specific stem cells called satellite cells that have the potential to differentiate into new fibers [32]. This type of myogenesis occurs when mature muscle is injured and satellite cells are activated, proliferate, and fuse to each other or.

Sep 30, 2009 · A popular theory in the stem cell field is that ‘regeneration recapitulates development’, or that adult stem cells function similarly to embryonic ones. In a recent Nature article, Lepper et al. questioned this approach, highlighting the differences in requirements for Pax7 during myogenesis for embryonic, juvenile and adult muscle.Cited by: 21. Other factors that appear to be involved in the regulation of adult muscle progenitors are HGF, FGFs, IGF-1 splice variants, myostatin, and TGF-β (Kuang et al. 2008; Bentzinger et al. 2010). The role of extrinsic regulatory factors in adult myogenesis is another example of analogy to the mechanisms regulating developmental muscle formation.Cited by: 606.

Aug 09, 2010 · Skeletal muscle postnatal growth and repair depend on satellite cells and are regulated by molecular signals within the satellite cell niche. We investigated the molecular and cellular events that lead to altered myogenesis upon genetic ablation of Syndecan-3, a component of the satellite cell niche. In the absence of Syndecan-3, satellite cells stall in S phase, leading to reduced. Therefore, alternative splicing is necessary in myogenesis. Systems approach. Systems approach is a method used to study myogenesis, which manipulates a number of different techniques like high-throughput screening technologies, genome wide cell-based assays, and bioinformatics, to identify different factors of a system.